Search results for "Carcinogen Metabolism"
showing 2 items of 2 documents
Synthetic antioxidants: biochemical actions and interference with radiation, toxic compounds, chemical mutagens and chemical carcinogens.
1984
Abstract Biological actions of 4 commonly used synthetic antioxidants — butylated hydroxyanisole, butylated hydroxytoluene, ethoxquin and propul gallate — on the molecular, cellular and organ level are compiled. Such actions may be divided into modulation of growth, macromolecule synthesis and differentiation, modulation of immune response, interference with oxygen activation and miscellaneous. Moreover, an overview of beneficial and adverse interactions of these antioxidants with exogenous noxae is given. Beneficial interactions include radioprotection, protection against acute toxicity of chemicals, antimutagenic activity and antitumorigenic action. Possible mechanisms of the antitumorige…
Antioxidants and carcinogen metabolism
1982
Abstract Supplementation of diet with synthetic antioxidants has been shown to protect animals against a broad spectrum of chemical carcinogens. Some interest has been expressed in the use of these food additives as possible prophylactic agents. However, such considerations appear premature in view of the fact that the protective mechanism has not yet been elucidated. The present communication reviews the effect of antioxidants on carcinogen-metabolizing enzymes, one of the major candidates in the interpretation of the protective antioxidant action.